Always consult your doctor about your medical conditions. With the development of high-throughput SNP genotyping technology and the availability of Hapmap data, it became possible to scan hundreds of thousands of SNPs that were in linkage disequilibrium with millions of SNPs across the genome. Support Center Support Center. These environmental factors clearly play a major role in the development of diabetes, but they do not impact everyone in the same way. HHEX was identified as one such gene in multiple studies in both Caucasian and Asian populations[ 58 ]. High levels can indicate that a child has a higher risk of developing type 1 diabetes. Does malnutrition in utero determine diabetes and coronary heart disease in adulthood?
The spectacular advances in information and technology arising out of the Human Genome Project [ 55 ], combined with the massive clinical resources available to the research community and a spirit of international collaboration exemplified by the efforts of the International Type 2 Diabetes Linkage Analysis Consortium, which acts as a forum for joint analysis of much of the world's type 2 diabetes genome scan data provide a solid basis for future developments in this field.
Genetics of Diabetes
Subsequent studies did not always confirm this finding but larger meta-analyses have shown that variants in CAPN10 are likely to be truly associated with T2D[ 17 ]. A genome-wide search for human non-insulin-dependent type 2 diabetes genes reveals a major susceptibility locus on chromosome 2. Suspect genes in other ethnic groups are less well studied. Lifestyle-related factors such as physical activity levels and diet are, next to age, the most important determinants of the penetrance of a given set of diabetes-susceptibility genotypes. Pro12Ala missense mutation of the peroxisome proliferator activated receptor gamma and diabetes mellitus.